The woman, a blonde named Samantha, 29, had to be saved by quick-thinking police as a mob gathered on the street, incensed by the chaos and damage she had caused.
She kept driving despite the erratic manner of her progress. Then she locked herself in the vehicle. Officers had to break a window to open a door and remove her.
The American woman screamed loudly after wreaking the damage and was handcuffed and driven off in the back of a police pickup about 5.45pm.
Among the angry crowd was a woman who was struck in a leg and taken to hospital for treatment, one of two people admitted. Her young son narrowly escaped injury.
''It was a crazy bit of driving,'' one police officer said. ''The American woman struck a motorcycle going the wrong side down the road then kept going. She turned a corner and kept hitting other vehicles, 13 at last count.''
The hit-run incident came in Siam Country Club soi, a one-way road.
Thais drive on the left side of the road and it's possible the American woman may have become disoriented.