A large crowd is expected at Surakul Stadium in Phuket City for the 4pm kickoff that closes the 34-match season.
Phuket, in 13th spot with 40 points, come up against JW Rangsit, in 16th spot with 31 points. Teams 15 to 18 face relegation after Saturday.
Four key players are injured for the critical match but coach Anurak Srikerd hopes the prospect of a second 300,000 baht bonus for a win - plus 30,000 baht for individual goals - will spur his team over the line.
Phuket needs to win just to make sure they stay above the relegation zone, but even a draw will attract an extra 100,000 baht for the players.
The teams that will close the season also opened it way back in March when Phuket and JW Rangsit played to a no-score draw away.
Coach Anurak is promising all-out attack to send off a season that promised so much and yet delivered just a little for Phuket.
One player who won't be wearing the Phuket green this week or ever aain in Brazilian keeper Alonso, who disappointed on the field and off.
He walked away with 124,200 baht in settlement on Tuesday despite his claims for two million baht, voiced loudly to some Phuket media and on Facebook.
The new season for Phuket begins on December 23 with 20 new players who have performed sufficiently well to earn a chance at the big time. Hopefully, it will be Division One.