The pileup, which saw one pickup mount the back of another and almost nosedive into a canal, came soon after 9am in wet weather outside the landmark Wang Talang lapidary store in Chao Fa Road West.
It is believed one pickup proceeding south from Phuket City lost control and crossed into the path of vehicles streaming north towards Phuket City.
Two people on the motorcycle were injured when the stream of traffic was pushed to the left and into each other.
The only positive was the location of the multiple crash. Rescue workers were able to divert the traffic heading towards Phuket City into the ''Out'' lane on the lapidary store and out the ''In'' lane.
Just a few hundred metres north of the crash, a long section of Chao Fa Road West now has a double line of plastic safety pillars down the middle of the road that prevents motorists overtaking or turning to slow the flow of vehicles.
The motorcycle ended up under one of the pickups and two people on the motorcycle are believed to have been the only casualties.
The crash followed a bus mishap on Patong Hill last night in which the vehicle failed to cope with the slope and slid back down towards Phuket City, tipping over and injuring 13 tourists from China and the two Thais on board.