The pair were on their way over Patong Hill to the west coast about 7.30pm last night when the rider, a British man, wrongly took a right hand turn at the Caltex intersection.
Heading towards Loch Palm instead of Patong, the rider quickly realised his mistake and attempted to make a u-turn.
However the motorcycle accelerated and the couple crashed into the open doorway of a house.
The woman complained of a sore head and the rider, who was wearing a helmet, suffered grazes.
Both were admitted to Vachira Phuket Hospital in Phuket City. It's not clear what experience the rider had had with motorcycles.