Next Saturday's Condor Air service is being flown by a 270-seat Boeing 767-300.
It's the latest sign that Phuket's popularity in Europe is continuing to grow and flourish despite a harsher economic climate there.
On Friday, the first flight in a new twice-weekly Thai Airways service from Stockholm to Phuket arrived to complement a year-old Copenhagen-Phuket service.
And a TUI Travel group Dreamliner will be coming to Phuket direct from Britain from November 5 next year in a breakthrough that indicates the right kind of economically and environmentally sensitive aircraft can encourage long-haul travel.
The Condor Air flights from Saturday land in Siem Reap - appealing because of the fabulous temples of Angkor Wat - at 6.05am and leave for Phuket at 7.25am before heading back to Franfurt later in the day.
An upgrade at Siem Reap airport is set to double its capacity to five million passengers by early 2013.
The Frankfurt-Siem Reap-Phuket flights will operate through until March.