Phuket police named the dead man as Einar Jan Frederik Bergstrom, 46.
He was the second Swedish fatality on Phuket this weekend. A man named as Matthias Andersson died in a fall from a balcony at a Karon resort.
Police said the latest death came when the man was killed instantly while taking a sharp bend, crashing with the car in the centre of the road.
The car went on to strike a parked vehicle. The collision came at 3.10am.
The man's body has been taken to Vachira Phuket Hospital in Phuket City.